2019: Articles in Press
Case Report

Cannabinoid Microdosing Improve Spasticity in a Traumatic Brain Injury Patient: A Case Study

Cury RM
Laboratory of Clinical Neuropharmacology, Faculty of Medicine, University of Latin American Integration, Foz do Iguaçu, PR, 85870-901, Brazil
Pamplona FA
Entourage Phytolab, Valinhos, SP, 13274-465, Brazil
Loss CG
Entourage Phytolab, Valinhos, SP, 13274-465, Brazil
da Silva EG
Laboratory of Clinical Neuropharmacology, Faculty of Medicine, University of Latin American Integration, Foz do Iguaçu, PR, 85870-901, Brazil
Nascimento FP
Laboratory of Clinical Neuropharmacology, Faculty of Medicine, University of Latin American Integration, Foz do Iguaçu, PR, 85870-901, Brazil
Published October 12, 2019
Keywords
  • THC,
  • Trauma brain injury,
  • CBD,
  • Spasticity,
  • Microdose

Abstract

A twenty-seven year old woman who suffered a severe traumatic brain injury (TBI) 10 years ago is the patient of this study. She has had a generalized spasticity on the right side presenting between 40 and 50 spasm crises by day, as well as cognition deficit, increased tonus and stiffness. Thus, our objective was to evaluate the therapeutics effects of a cannabis extract on this clinical condition. The clinical evaluation points were at days 7, 14, 45, 75, 105, 135 and 165. Spasms crises were evaluated 15 days before the treatment and 15 days after the start of treatment. Patient received microdose of cannabinoids for six months. The initial dose was around 170 µg of THC and 28 µg of CBD, dropping to 52 µg of THC and 7 µg of CBD by the end of treatment. The treatment reduced number of spasm, muscle tone, hyperreflexia and stiffness. Further, this treatment improved her cognition, short-term memory, speech, sense of humor, sleep and quality of life globally. This study shows for the first time that a very low dose of THC/CBD, in the order of micrograms, presented therapeutic effect in a human. Also, the ratio 6:1 between THC and CBD of this treatment is a new and interesting data to support new researches including cannabinoids and spastic syndrome.