Allogeneic Microvascular Tissue Graft Restores Healing Capacity in Recalcitrant Cleft Palate Fistula: A Case Report:
Copyright (c) 2019 Dobke et al.
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The closure of an anterior palatal fistula in a 23-year old female born with a severe class IV complete unilateral cleft lip and palate by means of local administration of an allogeneic microvascular tissue product (mVASC®) is reported. The patient had undergone 30 surgical procedures since 6 months of age, and had developed a recalcitrant oro-nasal fistula. Avascular and fibrous soft tissue surrounding the fistula was injected with mVASC in two series of injections several months apart as an office procedure. Anergic and fibrous tissue appeared to be more vascular and thicker within a few weeks, and the fistula healed within eight weeks following the resumption of semi-weekly mVASC injections after 20 years of failed multimodal attempts. Therapeutic potential of factors derived from perivascular tissue applicable to impaired healing is discussed in the context of presented case.