Purpose: Cytokines and hormones derived from adipose tissue are implicated in bone metabolism and atherogenesis. There is little data on the relationship between serum omentin-1 and vascular disease.  We aimed to investigate the relationship between levels of serum omentin-1 in Saudi postmenopausal females with and without subclinical atherosclerosis.

Methods: 126 postmenopausal women were recruited from the King Abdulaziz University Hospital in a case-control study design. Measurements were made of clinical biomarkers, including carotid intima: media thickness (CIMT) for all subjects.

Results: Serum omentin-1 levels were higher amongst postmenopausal women with subclinical carotid atherosclerosis than their age-matched controls (p<0.05). Only body weight and mean CIMT were shown to be independent predictors of serum omentin-1 levels by explaining 10.6% of the total variance according to the multiple regression model.

Conclusion: Serum omentin-1 levels are higher in postmenopausal women with evidence of early carotid atherosclerosis as assessed by CIMT and negatively associated with body weight.