The Cerebral Angiosarcoma of Pleuro-Pulmonary Origin: A Rapid Evolution and a Dark Prognosis of An Exceptional Localization
Introduction: Angiosarcoma is a rare malignant lesion apparently having its origin in the vasculature or precursor cells of the vessels. It comprises less than 1% of all sarcomas and may occur in any location of the body. It has predilection for skin and soft tissue. Brain metastasis from this lesion represents very extremely rare presentation.
Clinical case: We report the case of a 54-year old woman who complained of thoracic pain with subsequent
haemoptysis and rapid deterioration of the general state. Thoracic CT scan showed right pleural nodular thickening associated with ipsilateral pleural effusion with diffuse nodular and micro nodular infiltrate of both lungs. Abdominal CT scan showed a left adrenal mass. Forty eight hours later the patient presented a rapid deterioration of her neurological state. Cerebral CT scan showed a large left frontal-temporal osteolytic lesion. Decompressive craniectomy was necessary. Histological examination concluded angiosarcoma.
Conclusion: Angiosarcoma is a rare malignant sarcoma with local recurrence and distal metastasis. Radical surgery is the most useful method for treating this disease. Combination treatment based on chemotherapy is strongly recommended for advanced angiosarcoma, however, there is no standard chemotherapy regimen at present.