2019: Articles in Press
Research

The 9-bp Deletion at Position 8272 in Region V of Mitochondrial DNA is Associated with Outcome of Colorectal Cancer

Liu Q
Department of Thoracic Surgery, the Fourth Hospital of Hebei Medical University, Shijiazhuang, China
Xie S
Department of Thoracic Surgery, the Fourth Hospital of Hebei Medical University, Shijiazhuang, China
Jiao P
Department of Thoracic Surgery, the Fourth Hospital of Hebei Medical University, Shijiazhuang, China
Liu G
Department of Thoracic Surgery, the Fourth Hospital of Hebei Medical University, Shijiazhuang, China
Guo Z
Departments of Gastroenterology and Hepatology, the Fourth Hospital of Hebei Medical University, Shijiazhuang, China
Published May 2, 2019
Keywords
  • 8272,
  • Mitochondrial DNA,
  • mtMSI,
  • Outcome,
  • CRC

Abstract

The 9-bp deletion of CCCCCTCTA at position 8272 in region V of mitochondrial DNA is one of the mitochondrial DNA microsatellite instability (mtMSI) sites that associated with cancers. In the present study, we investigated the association of 8272 deletion with the cancer risk and outcome for colorectal cancer (CRC). By the log-rank analysis, the 8272 CCCCCTCTA/del was identified as a prognostic marker for outcome of colorectal cancer patients with the deleted ones associated with shorter postoperative survival. After adjusted with Cox Hazard model, this MSI was associated independently with CRC outcome (relative risk, 2.038; 95%CI, 1.20-3.707; p = 0.020). The analysis of mtMSI can help to identify patient subgroups that are at high risk for poor disease outcomes.