2019: Articles in Press
Articles

Expression of Angiogenin is inversely correlated to Progression of Gastric Tumors

Al-sarraf M
Department of Pharmacology, Pharmacy School of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China
Xiao-Tao H
Department of Integrative Traditional Chinese Medicine and Western Medicine, Women and Children’s Hospital of Hubei Province, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, China
Zhi-qiang Z
Department of Pathology, Hubei General Hospital of Chinese People’s Armed Police Forces, Wuhan, China
Bin L
Department of Pathology, Hubei General Hospital of Chinese People’s Armed Police Forces, Wuhan, China
Jing L
Department of Emergency, Hubei General Hospital of Chinese People’s Armed Police Forces, Wuhan, China
Yun-Xia W
Department of Pharmacology, Pharmacy School of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China
Published April 1, 2019
Keywords
  • Angiogenin,
  • Gastric Cancer

Abstract

Objective: Angiogenin (ANG) is upregulated in a variety of cancers including those of prostate, cervix, pancreas, liver, oral cavity, skin, and etc., however, the role of ANG in gastric cancer has not been fully elucidated yet. We use tissue microarray (TMA) to examine ANG expression to investigate the role of ANG in the progression of gastric cancer.
Method: Immunohistochemistry was used to evaluate ANG expression in TMA with 208 spots from 104 patients diagnosed with gastric cancer and the corresponding adjacent tissue.
Results: In normal adjacent tissue, ANG was expressed mainly in cytoplasm at basal gland of the gastric mucus where gastric stem cells are reserved, and also sparsely expressed in the nucleus of gastric mucosal gland cells at isthmus where gastric stem cells are gathered. In cancer tissues, ANG was very sparsely expressed in the nucleus of gastric glandular cells. ANG expression in the cytoplasm was found to be significantly associated with pathological types (p<0.001) and malignancy (p<0.001). ANG expression in the nucleus was inversely correlated with malignancy (p=0.019), differentiation status (p< 0.001), and tumor stage (p= 0.048).
Conclusion: ANG might play an important role in gastric cancer development.