Vol. 4 No. 1 (2018): Conference Proceedings: World Congress on Nutrition and Obesity Prevention Source 2017
Conference Proceedings

Poster Effect of Nizatidine on Olanzapine-Associated Weight Gain in Schizophrenic Patients

Won-Myong Bahk
Department of Psychiatry, Yeouido St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
Young-Joon Kwon
Department of Psychiatry, Soonchunhyang University Cheonan Hospital, Soonchunhyang University, Cheonan, Korea
Bo-Hyun Yoon
Department of Psychiatry, Naju National Hospital, Naju, Korea
Kwanghun Lee
Department of Psychiatry, College of Medicine, Dongguk University, Gyeongju, Korea
Sang-Yeol Lee
Department of Psychiatry, Wonkwang University Hospital, Wonkwang University School of Medicine, Iksan, Korea
Se-Hoon Shim
Department of Psychiatry, Soonchunhyang University Cheonan Hospital, Soonchunhyang University, Cheonan, Korea
Kyung Joon Min
Department of Psychiatry, College of Medicine, Chung-Ang University, Seoul, Korea

Published 2018-01-01

Abstract

A pilot study was conducted to evaluate the effect of nizatidine on olanzapine-associated weight gain (OAWG) in ten patientswith schizophrenia and schizophreniform disorder in Korea. Psychometric ratings with positive and negative syndromescale (PANSS) and brief psychiatric rating scale (BPRS) were measured at baseline, week 4 and week 8; as were weight and bodymass index (BMI). A combination of nizatidine for 8 weeks resulted in significant reversal of weight gain without worsening thepsychopathology (weight: 3.5% and BMI: 3.7%). In line with studies of Western populations, an add-on therapy of nizatidinecould be an effective option for the control of weight gain in olanzapine-treated patients in Korea. Our findings call for furtherevaluation of the effect of this drug on OAWG, with randomized placebo-controlled studies, in Asian populations.

Downloads

Download data is not yet available.