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Nutritional and metabolic processes involve numerous pathways. It is highly significant to clarify the presenceÃ‚Â and function of signaling molecules involved in each pathway. A Cbl-interacting protein of 85 kDa (CIN85) belongsÃ‚Â to a family of ubiquitously expressed adaptor/scaffold proteins. CIN85 is a multiadaptor protein implicated inÃ‚Â the regulation of receptor endocytosis, cell division, and the cellular cytoskeleton. Mice deficient in brain-specificÃ‚Â CIN85 expression shows aberrant dopamine signaling; insufficient complex formation of endophilins with D2 dopamineÃ‚Â receptors (D2DRs) in the striatum, an important center for the coordination of animal behavior and ultimatelyÃ‚Â decreased D2DR endocytosis in striatal neurons in response to dopamine stimulation. As a result, CIN85-deficientÃ‚Â mice exhibit the hyperactive phenotype. Here, we show other phenotypes of CIN85 deficient-mice; low levels ofÃ‚Â bone mineral density and blood glucose. From a perspective of nutritional research, the analysis of CIN85 and itsÃ‚Â deficiency in mice may lead to new developments in nutritional study.
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