Oral The Role of Homocysteine and B Vitamins in Telomere Length: Results from the Cross-Sectional and Interventional Trials

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Wolfgang Herrmann
Irene Pusceddu
Markus Herrmann
Winfried März
Susanne H Kirsch
Christian Werner
Ulrich Hübner
Marion Bodis
Ulrich Laufs
Stefan Wagenpfeil
Jürgen Geisel
Angela M Di Pierro
Silvia Giuliani
Marcus Kleber
Graciela Delgado


Telomeres are essential for the maintenance of genomic integrity. Telomere length declines with age and telomeredysfunction has been proposed as a biomarker for age-related diseases. Vitamin B12, B6 and folic acid are essential cofactorsfor numerous cellular processes including the synthesis of purines and nucleotides, DNA and protein methylation. B vitamindeficiencies and hyperhomocysteinemiaare risk factors for the development of age-related diseases. The aim of this study is toevaluate the effects of B vitamins on telomere biology.


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