Journal of Nutritional Biology
Vol. 4 No. 1 (2018): Conference Proceedings: World Congress on Nutrition and Obesity Prevention Source 2017
Conference Proceedings

Oral The Role of Homocysteine and B Vitamins in Telomere Length: Results from the Cross-Sectional and Interventional Trials

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  • Wolfgang Herrmann,
  • Irene Pusceddu,
  • Markus Herrmann,
  • Winfried März,
  • Susanne H Kirsch,
  • Christian Werner,
  • Ulrich Hübner,
  • Marion Bodis,
  • Ulrich Laufs,
  • Stefan Wagenpfeil,
  • Jürgen Geisel,
  • Angela M Di Pierro,
  • Silvia Giuliani,
  • Marcus Kleber,
  • Graciela Delgado
Wolfgang Herrmann
Department of Clinical Chemistry and Laboratory Medicine, Saarland University Hospital, Germany
Irene Pusceddu
Department of Clinical Chemistry and Laboratory Medicine, Saarland University Hospital, Germany
Markus Herrmann
Department of Clinical Pathology, District Hospital Bolzano, Italy
Winfried März
University of Mannheim, Germany
Susanne H Kirsch
Department of Clinical Chemistry and Laboratory Medicine, Saarland University Hospital, Germany
Christian Werner
Department of Cardiology, Saarland University Hospital, Germany; 5Department of Biometry and Epidemiology, Saarland University Hospital, Germany
Ulrich Hübner
Department of Clinical Chemistry and Laboratory Medicine, Saarland University Hospital, Germany
Marion Bodis
Department of Clinical Chemistry and Laboratory Medicine, Saarland University Hospital, Germany
Ulrich Laufs
Department of Cardiology, Saarland University Hospital, Germany
Stefan Wagenpfeil
Department of Biometry and Epidemiology, Saarland University Hospital, Germany
Jürgen Geisel
Department of Clinical Chemistry and Laboratory Medicine, Saarland University Hospital, Germany
Angela M Di Pierro
Department of Clinical Chemistry and Laboratory Medicine, Saarland University Hospital, Germany
Silvia Giuliani
Department of Clinical Chemistry and Laboratory Medicine, Saarland University Hospital, Germany
Marcus Kleber
University of Mannheim, Germany
Graciela Delgado
University of Mannheim, Germany
Published January 1, 2018
Copyright (c) 2018 Wolfgang Herrmann

Abstract

Telomeres are essential for the maintenance of genomic integrity. Telomere length declines with age and telomeredysfunction has been proposed as a biomarker for age-related diseases. Vitamin B12, B6 and folic acid are essential cofactorsfor numerous cellular processes including the synthesis of purines and nucleotides, DNA and protein methylation. B vitamindeficiencies and hyperhomocysteinemiaare risk factors for the development of age-related diseases. The aim of this study is toevaluate the effects of B vitamins on telomere biology.

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