Does Physical Activity Improve Ageing and/or Excess Calorie Induced Cognitive Impairment of Male Humans?
Copyright (c) 2020 Das et al
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Excess calorie consumption and sedentary life style interfere with cognitive behavior, particularly in the aged. People, deficient in micronutrient may suffer more under similar conditions. Such a population may be a target of study since no report exists in the Indian context. Study was carried out with 357 young (30.13± 0.24 yr) and 287 aged (58.62 ± 0.29 yr) human male subjects. Participants’ socio-economic status, health status, calorie and micronutrient consumption pattern, cognitive performance and self-reported physical activity level (PAL) were assessed. Cognitive functions in aged subjects with At Par (AP, Required amount) calorie diet deteriorated significantly (p<0.05) than young consuming AP calorie diet. Excess calorie (CE) consumption (> 30% of requirement) did not affect (p>0.05) cognitive functions of the young subjects compared to their AP calorie consuming counterparts. But the aged subjects consuming CE diet showed significant (p< 0.05) decline in cognitive activity compared to AP calorie diet consuming subjects of the same age group. While low PAL adversely affected cognition in both young and aged population, high PAL showed strong positive influence on cognitive function which was independent of ageing and excess calorie intake. When ageing related neuronal loss is viewed as a cause of cognitive deficit in the aged, high level of super oxide production due to excess calorie consumption may be the other reason of cognitive deterioration among the aged. Aging-induced cognitive loss and excess calorie-induced cognitive impairment, among subjects with micronutrient deficiency, are prominent with low PAL, while high PAL masked the influence of aging and excess calorie-induced cognitive decline. Choice of appropriate diet along with maintenance of an active lifestyle with optimum calorie consumption may help to prevent/compensate aging- and excess calorie-induced cognitive loss and/or impairment.