Oral Marvelous Millet and its Bioactives Prevents Diet Induced Obesity in Mice
Main Article Content
Abstract
Excess calorie intake than expenditure leads to weight gain, obesity and associated comorbidities due to low-grade inflammation, oxidative stress, altered adipose tissue secretome and dysbiosis of beneficial gut microflora. Consumption of whole grains and their bioactives (polyphenols, dietary fibres) and prebiotics and probiotics have been suggested as alternate approaches for obesity management. Millets, belong to whole grain category, are rich in dietary fibres, proteins, energy, minerals, vitamins and antioxidants. Finger millet, also known as ragi, is an important food crop and has been shown to alleviate diabetic complications. There are no reports on the protective effects of finger millet whole grain, bran and its bioactives on rodent models of high-fat diet-induced obesity and associated gut bacterial dysbiosis. Our research strongly suggested that finger millet whole grain, bran, its dietary fiber and polyphenol extract supplementation protected the mice from high-fat diet induced obesity. Finger millet and its bioactives prevented body weight gain, improved lipid profile and anti-inflammatory status, alleviated oxidative stress, regulated the expression of several obesity-related genes, increased beneficial gut bacteria (Lactobacillus, Bifidobacteria and Roseburia) and suppressed the abundance of Enterobacter in caecal contents. Data suggests that inclusion of finger millet in regular diet could be beneficial for the management of metabolic diseases.
Downloads
Article Details
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).