Vol. 3 No. 1 (2020)
Review Article

MicroRNA-126 (MiR-126): A Crucial Player in the Retina

Published 2020-04-13


The MiR-126 is a highly conserved, non-coding RNA that is primarily expressed in human endothelial cells and is a crucial regulator of angiogenesis and vasculogenesis [1]. In human genomes, MiR-126 is found within intron 7 of the Epidermal Growth Factor-Like domain 7 (EGFL7) gene on chromosome 9 [2,3]. Processing of pre-MiR-126 i.e., the precursor miRNA, generates two mature strands: a) MiR-126-3p with the sequence: UCGUACCGUGAGUAAUAAUGCG and b) MiR-126-5p with the sequence: CAUUAUUACUUUUGGUACGCG [4,5].