Vol 1 No 1 (2018): Current Issue
Research Article

Alarin: A Novel Circulating Peptide Hormone Linked to Luteinizing Hormone and Hiperandrogenismin Polycystic Ovary Syndrome

Mehmet Calan
Division of Endocrinology and Metabolism, Department of Internal Medicine, Izmir Bozyaka Training and Research Hospital, 35170 Bozyaka, Izmir, Turkey
Merve Bicer
Department of Obstetrics and Gynecology, Medical Park Hospital, 35575, Izmir, Turkey
Murat Alan
Department of Obstetrics and Gynecology, Izmir Tepecik Training and Research Hospital, 35120 Tepecik, Izmir, Turkey
Pinar Alarslan
Division of Endocrinology and Metabolism, Department of Internal Medicine, Izmir Bozyaka Training and Research Hospital, 35170 Bozyaka, Izmir, Turkey
Asli Guler
Department of Family Physician, Izmir Bozyaka Training and Research Hospital, 35170 Bozyaka, Izmir, Turkey
Gokcenunal Kocabas
Division of Endocrinology and Metabolism, Department of Internal Medicine, Izmir Bozyaka Training and Research Hospital, 35170 Bozyaka, Izmir, Turkey
Cetin Imamoglu
Department of Radiology, Izmir Bozyaka Training and Research Hospital, 35170 Bozyaka, Izmir, Turkey
Murat Aksit
Department of Biochemistry and Clinical Biochemistry, Izmir Tepecik Training and Research Hospital, 35120 Tepecik, Izmir, Turkey
Giray Bozkaya
Department of Biochemistry and Clinical Biochemistry, Izmir Bozyaka Training and Research Hospital, 35170 Bozyaka, Izmir, Turkey
Ahmet Cagdas Acara
Department of Emergency Medicine, Izmir Bozyaka Training and Research Hospital, 35170 Bozyaka, Izmir, Turkey
Ali Baloglu
Department of Obstetrics and Gynecology, Private Gynecology Clinic 35172 Alsancak, Izmir, Turkey
Behnaz Aslanipour
Department of Bioengineering, Faculty of Engineering, EgeUniversity, Izmir, Turkey
Published November 21, 2018
Keywords
  • Polycystic ovary syndrome,
  • Alarin,
  • Luteinizing hormone,
  • Androgens

Abstract

Alarin is a newly identified peptide hormone. It is implicated that alarinplays roles in regulation of energy metabolism and hypothalamo-pituitary-gonadal axis. Polycystic Ovary Syndrome (PCOS) is a common reproductive and metabolic disease in women during reproductive ages. Over-secretion of Luteinizing Hormone (LH) causes hyperandrogenism in women with PCOS. The purpose of the study was to determine the comparison of alarin levels in women with or without PCOS as well as to investigate the relationship between alarin and LH. Eighty-four women with PCOS and 84 age- and BMI- matched controls were recruited in this cross-sectional study. Circulating alarin levels were assessed via ELISA method. The hormonal and metabolic parameters of the recruited subjects were also determined. The circulating levels of alarin in PCOS subjects were higher than controls (6.11 ± 1.91 vs. 3.93 ± 1.60 ng/ml, P <0.001). Alarin showed a positive correlation with insulin resistance marker, BMI, LH and androgens. Moreover, alarin levels were elevated in women with PCOS having insulin resistance compared to those PCOS women without insulin resistance. In both control and PCOS groups, overweight subjects showed an elevation in circulating levels of alarin with respect to normal weight subjects. In the present study, Alarin level with the highest tertile dosage comparing to alarin level with the lowest tertile dosage could highly increase the probability of PCOS risk prevalence in women. Elevated alarin levels in women with PCOS were associated with not only LH and metabolic parameters but also high probability of having PCOS risk independently.

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