Vol 1 No 1 (2018): Current Issue
Review Article

Ovarian Tissue Cryopreservation from Contemporary Indications to Cutting Edge Research: A Review

Man L
The Ronald O. Perelman and Claudia Cohen CRM, Weill Cornell Medical College, New York, NY, USA
Rosenwaks Z
The Ronald O. Perelman and Claudia Cohen CRM, Weill Cornell Medical College, New York, NY, USA
James D
The Ronald O. Perelman and Claudia Cohen CRM, Weill Cornell Medical College, New York, NY, USA
Published May 5, 2018
Keywords
  • Fertility preservation,
  • Ovarian tissue cryopreservation,
  • Indications,
  • Outcomes,
  • Reintroducing malignancy,
  • Prepubertal girls,
  • Experimental models
  • ...More
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Abstract

Over the last three decades, survival rate from malignancies has steadily increased, turning major focus on quality of life in remission. Unfortunately, a major side effect of medical interventions including chemotherapy, radiotherapy, and/or surgery is premature ovarian failure and infertility for many patients. Ovarian tissue cryopreservation is an experimental technique used to preserve reproductive potential in patients who are pre-pubertal, must urgently undergo gonadotoxic treatment or who have other medical conditions requiring treatment that may undermine ovarian reserve and will lead to sub or infertility. We will review the indications, available techniques of tissue harvesting, and methods for freezing and autotransplanting cortical ovarian tissue. We will discuss outcomes, the potential risk of reintroducing malignancy and lastly, cutting-edge research models being developed in the field.