2019: Articles in press
Case Report

Acute Psychosis Associated with Septo-Optic Dysplasia (De Morsier Syndrome): A Case Report

Goyal DK
Department of Psychiatry, University of Nevada, Reno, USA
Singal A
University of San Francisco, San Francisco, USA
Goyal A
Memorial Health System, Marietta, Ohio, USA
Sandhu G
University of South Dakota, Vermillion, USA
Published January 29, 2019
  • Septo-optic dysplasia,
  • Psychosis,
  • Optic nerve hypoplasia,
  • Pituitary insufficiency
How to Cite
DK, G., A, S., A, G., & G, S. (2019). Acute Psychosis Associated with Septo-Optic Dysplasia (De Morsier Syndrome). Annals of Behavioral Neuroscience, 2(1), 133-135. https://doi.org/10.18314/abne.v2i1.1515


Background: Septo-optic dysplasia (SOD), a variable combination of abnormalities of cerebral midline structures, is a clinically heterogeneous syndrome. Psychiatric symptoms in SOD were implicated in one case due to abnormal regulation of neuroendocrine structures.
Objective: Discussion of a case of SOD associated with psychosis and depression, exploring the role of anatomical and endocrine abnormalities in producing psychiatric symptoms.
Methods: Literature was reviewed on the PubMed, Medline, and Web of Science. One case of SOD with psychosis was reported in 2008.
Conclusions: Disruption of complex neural pathways, including the septum pellucidum and other limbic structures may have been involved in the psychiatric disturbances in this case. Further reporting of similar cases is needed for more understanding of these associations.