An Integrative Immunobiology and Inflammation Study on Cytomegalovirus
AbstractThe human immune system plays a cardinal role in host defense against the assault of foreign agents, particularly that from microbes, such as bacteria, fungi, or viruses of which human cytomegalovirus serves as an example. Immune reactions consist of inflammation, however, either hyper or hypo inflammatory reaction results in diseases. Additionally, host immunity operates a dynamic balance of symbiosis among host and microbes, at both intracellular and extracellular levels. We aim to harness the knowledge and technology in studying this ubiquitous opportunistic virus, its interplay with the host immune system, evading immune response, exacerbating inflammation, and causing damage in host whereas in symbiosis with the host DNA genome. We will address how we define the tipping point of immunity and inflammation, via study the mechanism of the immune reconstitution inflammatory syndrome, as well as the mechanism of this diminutive mega creature causing cardiovascular injury in immune competent individuals, to develop and comply an immunomodulation, to reprogram patient immunity against the viral infections, including immunity against human immunodeficiency virus, towards a cure of AIDS.
Sep 15, 2016
How to Cite
ZHANG, Jielin; CRUMPACKER, Clyde. An Integrative Immunobiology and Inflammation Study on Cytomegalovirus. Integrative Immunobiology and Inflammation, [S.l.], v. 1, n. 1, sep. 2016. Available at: <http://www.gratisoa.org/journals/index.php/IJII/article/view/88>. Date accessed: 24 may 2017.
This work is licensed under a Creative Commons Attribution 4.0 International License.Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under aÂ Creative Commons Attribution LicenseÂ that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (SeeÂ The Effect of Open Access).