An Integrative Immunobiology and Inflammation Study on Cytomegalovirus

Main Article Content

Jielin Zhang Clyde Crumpacker

Abstract

The human immune system plays a cardinal role in host defense against the assault of foreign agents, particularly that from microbes, such as bacteria, fungi, or viruses of which human cytomegalovirus serves as an example. Immune reactions consist of inflammation, however, either hyper or hypo inflammatory reaction results in diseases. Additionally, host immunity operates a dynamic balance of symbiosis among host and microbes, at both intracellular and extracellular levels. We aim to harness the knowledge and technology in studying this ubiquitous opportunistic virus, its interplay with the host immune system, evading immune response, exacerbating inflammation, and causing damage in host whereas in symbiosis with the host DNA genome. We will address how we define the tipping point of immunity and inflammation, via study the mechanism of the immune reconstitution inflammatory syndrome, as well as the mechanism of this diminutive mega creature causing cardiovascular injury in immune competent individuals, to develop and comply an immunomodulation, to reprogram patient immunity against the viral infections, including immunity against human immunodeficiency virus, towards a cure of AIDS.

Article Details

How to Cite
ZHANG, Jielin; CRUMPACKER, Clyde. An Integrative Immunobiology and Inflammation Study on Cytomegalovirus. Integrative Immunobiology and Inflammation, [S.l.], v. 1, n. 1, sep. 2016. Available at: <http://www.gratisoa.org/journals/index.php/IJII/article/view/88>. Date accessed: 18 oct. 2017.
Section
Articles

Most read articles by the same author(s)

Obs.: This plugin requires at least one statistics/report plugin to be enabled. If your statistics plugins provide more than one metric then please also select a main metric on the admin's site settings page and/or on the journal manager's settings pages.