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Objective: Tissue acquisition is the gold standard for diagnosis and characterization of gastric subepithelial tumours (SETs). We present our experience with endoscopic incisional tissue acquisition (ITA) technique in hypoechoic SETs of the fourth layer at EUS examination.
Methods: The ITA technique was performed in 32 patients. The mean size of the lesions was 19 mm, and the gastric body was the most common location. The mean procedure time was 19 minutes; a mean of 4 biopsies per lesion were taken.
Results: Tissue samples were adequate for histological diagnosis in 30/32 cases (diagnostic yield 94%). The most frequent histological pattern was gastrointestinal stromal tumour in 20 cases. Surgical resection was performed in 12 cases, while the remaining patients were followed without additional therapy.
Conclusion: Endoscopic ITA technique is a safe and effective sampling method for histological diagnosis of gastric SETs.