Abstract

Background: Type 2 diabetic women are at higher risk of developing atherogenicdyslipidemia. The major possiblerisk factorsare obesity, abdominal fat accumulation and poor glycaemic control. However, menopause-relatedchanges could be anotherdeterminant. The aim of this study was to evaluate the interrelationships of these risk factorsand their independent effects onatherogenic indices in type 2 diabetes women.


Methods: A prospective, cross-sectional study, which includes 160 women agreed to participate in this study.Anthropometrics,biochemical parameters and blood pressure were measured. Atherogenic indices - total cholesterolto-high-density lipoproteincholesterol ratio (TC/HDL) and apolipoprotein (apo) B-to-apo A1 ratio, were calculated.Individual risk factors were examinedin relationship to these atherogenic indices using correlation tests and logisticregression.


Results: 23.12% of the participants were normal weight and 76.87% were overweight/obese. The overall mean agewas57.70±11.16 years. Diabetes duration (>5years), anthropometric parameters, poor glycaemic control, high apo Band high levelof low-density lipoprotein (LDL) were found to be significant determinants of atherogenic indiceschanges. The TC/HDL ratiowas weakly associated with both BMI and waist circumference. However, the apo B/apoA1 ratio provided positive correlationswith anthropometric parameters, especially with waist circumference(p=0.185, r=0.108, r2=0.012), and this, in both pre andpost-menopausal type 2 diabetic women.


Conclusions: The atherogenic risk, estimated by TC/HDL and apo B/apo A1 ratios, becomes more severe withhigheranthropometric parameters (BMI and waist circumference), diabetes duration and poor glycaemic control in type2diabetes women and this during both premenopausal and postmenopausal periods.