Obesity and weight changes are important factors affecting the lipid profile. In this study, the relationship between 4-yearschanges in weight with serum lipid profile in men 25 to 60 years old was investigated. Anthropometric indices and lipidprofiles of 217 men employed in an Iranian petrochemical company in 2012 and 2016 were collected through their medicalrecords. All subjects were non-smoker. In both periods of data collection, no use of lipid lowering drugs (from 6 months beforethe sampling), absence of chronic diseases (such as diabetes, hypothyroidism, etc.) have reported. After four years of followup, means of weights, BMI, TC, TG and LDL-C significantly increased and HDL-C levels decreased significantly. In the lastassessment (2016), after adjustment for all potential confounding variables, the chances of having hypercholesterolemia (OR= 2.2 and P <0.05) and hypertriglyceridemia (OR = 3.1 and P <0.01) in obese subject was significantly more than those withnormal BMI. There was a positive and significant correlation between changes in BMI with TC and LDL-C (R = 0.15, p <0.05and R = 0.29, p <0.01 respectively). The changes in TC and LDL-C were significantly higher in men whose BMI increased morethan 1kg / m2 (n = 74). In subjects studied in the fourth quartile, compared with the lowest quartile of BMI changes, the chanceof having hypercholesterolemia were 3.76 (95% CI: 1.6-8.7) and LDL-C was 2.75 fold (95% CI: 1.1-6.7). Weight gain and BMIare associated with increased levels of TC, LDL-C, and HDL-C.

Biography:Shekoofeh Salamat, 32 years old, come from Iran. BSc. of nutrition and dietetics, graduated from Ahvaz Jundishapour Universityof Medical Sciences in 2006. Employed in Narges hospital in Mahshahr for 1 year and employed in Arvand petrochemicalcompany as a nutritionist since 2008. Student of MSc. of nutrition at ajums.