Oral The Role of Homocysteine and B Vitamins in Telomere Length: Results from the Cross-Sectional and Interventional Trials

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Wolfgang Herrmann Irene Pusceddu Markus Herrmann Winfried März Susanne H Kirsch Christian Werner Ulrich Hübner Marion Bodis Ulrich Laufs Stefan Wagenpfeil Jürgen Geisel Angela M Di Pierro Silvia Giuliani Marcus Kleber Graciela Delgado


Telomeres are essential for the maintenance of genomic integrity. Telomere length declines with age and telomeredysfunction has been proposed as a biomarker for age-related diseases. Vitamin B12, B6 and folic acid are essential cofactorsfor numerous cellular processes including the synthesis of purines and nucleotides, DNA and protein methylation. B vitamindeficiencies and hyperhomocysteinemiaare risk factors for the development of age-related diseases. The aim of this study is toevaluate the effects of B vitamins on telomere biology.

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