Drosophila Species as Models for Nutritional Studies: Development, Metabolic Pools on Diets with Contrasting Relative Sugar: Protein Ratios

  • Therese Ann Markow University of California San Diego
  • Nestor Nazario-Yepiz LANGEBIO-CINVESTAV
  • Mariana Ramirez Loustalot-Laclet LANGEBIO-CINVESTAV

Abstract

We examined development time, survival, adult body weights, and metabolic pools of protein, triglycerides and glycogen in three Drosophila species reared on three isocaloric diets differing in their relative ratios of sugar to protein. Drosophila melanogaster, a fruit breeder, survived and developed well on all three diets. But two other species, the cactophilic D. arizonae and D. mojavensis, normally accustomed to low carbohydrate resources in nature, were significantly impaired by diets higher in sugar. As expected, based upon their natural history, D. arizonae was less affected than D. mojavensis. These species, whose genomes are sequenced and have many homologues with human metabolism genes, provide an inexpensive and tractable model system to study human metabolic diseases related to excess dietary sugar.
Published
Feb 3, 2017
How to Cite
MARKOW, Therese Ann; NAZARIO-YEPIZ, Nestor; RAMIREZ LOUSTALOT-LACLET, Mariana. Drosophila Species as Models for Nutritional Studies: Development, Metabolic Pools on Diets with Contrasting Relative Sugar: Protein Ratios. Journal of Nutritional Biology, [S.l.], v. 3, n. 1, feb. 2017. ISSN 2469-4142. Available at: <http://www.gratisoa.org/journals/index.php/GJFN/article/view/108>. Date accessed: 28 june 2017. doi: http://dx.doi.org/10.18314/jnb.v3i1.108.