Abstract

To check the occurrence of Extrapyramidal Symptoms (EPS) and Hyperprolactinemia (HP) in Schizophrenic patients receiving Risperidone drug and to check the efficacy of the drugs used for the management of these side effects. The study assumes significance in light of reported data that anticholinergic drugs are not very effective in relieving side effects and that they may impair efficacy of antipsychotic drugs to relieve positive symptoms. 30 Schizophrenic patients receiving Risperidone drug were assessed for EPS & HP using Simpson Angus Rating Scale (SAS), Barnes Akathisia Rating Scale (BARS), Abnormal Involuntary Movement Scale (AIMS) & estimating prolactin level in blood. The EPS and HP side effects were treated with Trihexiphenidyl, propranolol or diazepam
and cabergoline respectively and efficacy was studied for resolving the symptoms. The study revealed that 54.83% of patients on Risperidone showed EPS; majority of these patients (48.38%) developed Parkinsonism and rest (6.45%) developed Akathisia. Besides, 6.45% of the patients developed HP manifested as amenorrhea and menstrual irregularities. Trihexiphenidyl brought about resolution of most (88%) patients with Parkinsonism and partial resolution in remaining patients where tremors & rigidity persisted. propranolol and diazepam brought
about the resolution of Akathisia. Cabergoline brought about satisfactory resolution of HP & associated symptoms in all the cases. About 65% of the patients receiving risperidone drug exhibited perceptible side effects. EPS, particularly Parkinsonism was found to be the major adverse effect. All the side effects were adequately resolved by the conventional drugs even at lower levels of the recommended dose improving the compliance of the treatment.